Depression Has A Genetic Cause
When people talk about someone being “depressed” most often they are referring to what medical professionals term “unipolar depression”. Other terms used to describe the condition are “clinical depression”, “major depressive illness”, and “major depression with melancholic features”. Regardless of the name, all these refer to the same illness located in the same region of the brain, damaging the same cells and causing the same chemical imbalances. Other conditions that also have “depression” in their name for example “bipolar depression” are very different in the cells and chemicals affected.
Over the last several decades medical research has established a definite genetic link for unipolar depression. If one of your parents and other members of your immediate family are afflicted with unipolar depression you have a one in five (20%) chance of suffering it yourself. Should both parents have the depressive gene your odds of being depressive as well fall to one in two (50%). But even when no one in your family suffers from unipolar depression, or has the genetic marker, the genes can and do show up spontaneously.
Just how important this genetic component is has been proven by studies that focused on people with identical genes (twins) but, for a variety of reasons, were raised apart by different parents. These studies concluded that, if both twins had the depression gene, both individual were most likely suffering from unipolar depression regardless of the different life experiences and conditions.
The genes that have been identified as causing unipolar depression act by causing the brain to over react to stress stimulation. It is normal for everyone to secrete a steroid stress hormone into the body and certain chemicals into the brain when faced with a stressful situation. Although this process is completely normal, those who suffer from unipolar depression don’t turn off these hormones and chemicals when the stress is past. And when these substances remain at high levels for too long a time, they cause severe damage to healthy brain cells which is a major contributing cause to the disease.
For example, athletes who perform at high levels often release steroid stress hormones to meet a physical challenge such as catching a pass or hitting a baseball in a pressure situation. This happens for just a short period of time, once the immediate challenge is past the athlete’s body turns off the stress response and the body reverts to its normal state.
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In those people who carry the genes responsible for unipolar depression these responses to stress are not able to be turned off. All the normal stresses of everyday life cause large amounts of the steroid stress hormones and other chemicals to flood the brain and this overload causes severe damage to otherwise healthy brain cells which eventually brings on unipolar depression.